ANESTHESIOLOGY IN THE LIGHT OF THE TRANSFORMATIONS OF THE THEORY OF STRESS AND ADAPTATION. PERSPECTIVE OR SKEPTICISM OF PRACTICAL USE? (literature review)

The article attempts to analyze the main modern transformations of theory stress and adaptation possibility implementing anti-stress reactions general anesthesia. One central non-specific mechanisms stressor injury has been found be stimulation free-radical processes as a result often concomitant hypoxemia / hypoxia prooxidant effects catecholamines. Data on regulatory adaptive effect FR products (AOS nitrogen) in regulation gene expression increased production antistress proteins, mitochondrial biogenesis normalization energy metabolism are presented. discussions "apologists" adaptology about "integral" indicators type functional state organism given. Emphasis is placed anesthesiologist's understanding that relatively open selforganizing self-structured dissipative system, well critical view mathematical method evaluating organism.